Mark Renton is finally a success. An international jet-setter, he now makes significant money managing DJs, but the constant travel, airport lounges, soulless hotel rooms and broken relationships have left him dissatisfied with his life. He's then rocked by a chance encounter with Frank Begbie, from whom he'd been hiding for years after a terrible betrayal and the resulting debt. But the psychotic Begbie appears to have reinvented himself as a celebrated artist and - much to Mark's astonishment - doesn't seem interested in revenge. Sick Boy and Spud, who have agendas of their own, are intrigued to learn that their old friends are back in town, but when they enter the bleak world of organ-harvesting, things start to go so badly wrong.